ar cell - In addition doubleknockout mice models could gambar motor 2d be applied to further delineate the AR roles For example cell typespecific ARKO and ARER doubleknockout mice are needed to determine AR roles and its possible interaction with the ER in ovarian folliculogenesis and other functions in the female reproductive system Supplementary Material Androgen Receptor AR Physiological Roles in Male and Female AR Androgen Receptor is a Protein Coding gene Diseases associated with AR include Androgen Insensitivity Partial and Spinal And Bulbar Muscular Atrophy XLinked 1Among its related pathways are Gene expression Transcription and Signaling by Rho GTPasesGene Ontology GO annotations related to this gene include DNAbinding transcription factor activity and chromatin binding Molecular features regulating DNA binding and the transactivation activities of the androgen receptor AR and the greater steroid receptor family have remained elusive Using cryoEM and mass spectrometry Wasmuth et al reveal a tunable mode of dimerization and define allosteric surfaces important for AR activities and development Cellbased assays for screening androgen receptor ligands 11 AR regulates cell cycle control The means by which ligandactivated AR initiates the cell cycle has been generally defined ADTsensitive cells deprived of androgen exit the cell cycle and arrest in G0 Agus et al 1999 Huggins and Hodges 1972 Knudsen et al 1998Transitions into and within the cell cycle are controlled by cyclincyclindependent kinase cdk complexes which act The data herein demonstrate that the ARdependent transcriptional networks governing these cancerassociated activities are regulated as a consequence of cell cycle position further underscoring the importance of ARcell cycle interplay in promoting gene expression networks and suggesting implications for tumors with alterations in cell cycle NRLBDAR Ligand binding domain of the nuclear lazawin receptor androgen receptor ligand activated transcription regulator cd07173 Location 23 104 NRDBDAR DNAbinding domain of androgen receptor AR is composed of two C4type zinc fingers NM0013480611 NP0013349901 androgen receptor isoform 3 Status REVIEWED Description Prostate cancer cells are exquisitely dependent on androgen receptor AR activity for proliferation and survival As these functions are critical targets of therapeutic intervention for human disease it is imperative to delineate the mechanisms by which AR engages the cell cycle engine More than AR Gene GeneCards ANDR Protein ANDR Antibody The AR gene is located on the X chromosome at the locus Xq11Xq12 161718The protein coding region has 2757 nucleotides and spans eight exons with introns that vary in size from 07 to 26 kb AR androgen receptor Homo sapiens human Gene NCBI In some cell types testosterone interacts directly with androgen receptors whereas in others testosterone is converted by 5alphareductase to dihydrotestosterone an even more potent agonist for androgen receptor activation 15 Testosterone appears to be the primary androgen receptoractivating hormone in the Wolffian duct whereas dihydrotestosterone is the main androgenic hormone in A recently reported AR cell bioassay more selective then those previously described was developed by Lee JH et al The group developed a detection system for androgenic and antiandrogenic compounds which was based on yeast twohybrid protein interactions A yeast strain ARhLBDASC1 was established by cotransformation of yeast cells Allosteric interactions prime androgen receptor Cell Press Androgen receptor Wikipedia The AR dependent cell cycle Mechanisms and cancer relevance Androgen receptor structure role in prostate cancer and drug The AR dependent cell cycle mechanisms and cancer relevance Cellcycle coupled expansion of AR diperlamakan4d activity promotes cancer progression
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