meloxicam paten - US Patent Application for Justia Patents kepalaslot Search Highly Concentrated Stable Meloxicam Solutions for Needleless Solution of meloxicam consisting of the meglumine salt of the active Substance Sodium chloride and water 0003 EPA0945 134 discloses the pHdependent solu bility characteristics of meloxicam and its salts ie the Sodium salt the ammonium salt and the meglumine salt in aqueous solution According to this meloxicam is an active Nanoparticulate meloxicam formulations Google Patents 0005 Meloxicam is a hydrophobic drug and diffucult to dissolve in aqueous solution Meglumine can increase the solubility of meloxicam in aqueous solution Zhao J Zhang JS Journal of China Pharmaceutical University Study on the solubilization of meloxicam in meglumine aqueous solution 2003 Vol34 No5 abstract Meglumine is an US6869948B1 Meloxicam for oral administration Google Patents WO2006061351A1 Oral suspension comprising meloxicam Aqueous cyclodextrinfree solution of meloxicam for administration by oral or parenteral route containing a pharmacologically acceptable meloxicam salt of an organic or inorganic base and one or more suitable excipients the content of dissolved meloxicam salt being more than 10 mgml US Patent Application for Nanoparticulate Meloxicam The invention relates to a synthesis method of meloxicam belonging to the field of medicine synthesis The method comprises the following steps of adding 4hydroxyl2methyl2H12benzothiazine3ethyl formate11dioxide and 2amino5methylthiazole into dimethyl sulfoxide reacting at a certain temperature while steaming out ethanol after the reaction adding a certain amount of ethanol 19 United States 12 Patent Application Publication 10 Pharmaceutical formulations of meloxicam European Patent An orally administerable meloxicam tablet formulation comprises meloxicam 01 to 5 by weight one or more fillers such as lactose and silicified microcrystalline cellulose 70 to 95 by weight one or more stabilising agents preferably sodium citrate 1 to 10 by weight one or more disintegrating agents such as crosslinked Nvinyl2pyrrolidone 1 to 5 by weight one or more WO2001097813A2 Highly concentrated stable meloxicam Pharmaceutical compositions of meloxicam Google Patents US Patent Application for Novel formulation of meloxicam Apr 21 2022 Manufacturing procedure of Composition A and B About 60 required quantity of water for injection was taken in two beakers Beaker 1 and 2 5 and 625 grams of meglumine was added to the Beaker 1 and 2 respectively and stirred for about 510 minutes at 500 RPM to obtain clear solutions 15 and 375 grams of meloxicam was added to the clear solutions of Beaker 1 and 2 respectively and The invention relates as described in claim 1 to aqueous cyclodextrinfree solutions of meloxicam for needlefree intracutaneous or subcutaneous administration which contain a pharmacologically acceptable meloxicam salt of an organic or inorganic base in a highly concentrated solution with 35 to 100 mgml of meloxicam together with suitable Meloxicam Paten Image Results 20190825 Priority to US16550239 priority Critical patentUS10709713B2en 20191219 Publication of US20190381062A1 publication Critical patentUS20190381062A1en 20200130 Assigned to BAUDAX BIO INC reassignment BAUDAX BIO INC ASSIGNMENT OF ASSIGNORS INTEREST SEE DOCUMENT FOR DETAILS Assignors RECRO PHARMA INC Generic MELOXICAM INN entry pharmaceutical patent expiration US9808468B2 Formulation of meloxicam Google Patents US Patent Application for Justia Patents Search The invention relates in its first aspect to a rapidly decomposing tablet for pain therapy containing meloxicam 4hydroxy2methylN5methyl2thiazolyl2H12benzothiazine3carboxamide11dioxide in the form of a salt with an inorganic or organic base providing rapid absorption of the active substance the process of its preparation by direct tabletting and furthermore relates in a GB2455875A Meloxicam tablet formulations and their US Patent for Pharmaceutical compositions comprising Videos for Meloxicam Paten US Patent Application for STABLE Justia Patents Search Nov 22 2005 Meloxicam is a NSAID angka 23 that exhibits antiinflammatory analgesic and antipyretic activities in animal models Meloxicam is approved for use in the United States and is sold as Mobic Tablets in 75 mg and 15 mg forms for oral administration See Physicians Desk Reference p 1016 Thomson P D R 2004 It has also been produced as an oral Sep 25 2020 In another embodiment the present invention provides a meloxicam injection in a singledose prefilled syringe with an autoinjector wherein the meloxicam is present in a therapeutically effective dose amount from about 75 mg to about 60 mg for example 10 mg 15 mg 20 mg 25 mg 30 mg 35 mg 40 mg 45 mg 50 mg or 55 mg Nov 1 2022 Superiority of meloxicamrizatriptan to rizatriptan active comparator and MoSEIC meloxicam component contribution was established as specified in the SPA by the demonstration of a greater percentage of patients receiving meloxicamrizatriptan achieving sustained pain freedom from 2 hours to 24 hours after dosing compared to rizatriptan CN102775401A Synthesis method of meloxicam Google Patents Mar 18 2021 The dissolution rate of meloxicam 5 mg and 10 mg capsules was analyzed For the 5 mg capsules the dissolution conditions were USP Apparatus 1 baskets set to rotation speed of 100 RPM in 500 mL of pH 61 phosphate buffer with 01 sodium lauryl sulfate SLS at 37 C05 C Nov 28 2024 What are the generic drug sources for meloxicam and what is the scope of patent protection Meloxicam is the generic ingredient in five branded drugs marketed by Lupin Ltd Novitium Pharma Iceutica Operations Baudax Avondale Pharms Tersera Aiping Pharm Inc Anda Repository Ascent Pharms Inc Aurobindo Pharma Chartwell Rx Cipla Corepharma Cr Double Crane Dr Reddys Labs Inc Glenmark May 10 2019 CROSSREFERENCE TO RELATED APPLICATIONS This application is a US national entry of PCT International Application No PCTCN2019086424 filed May 10 2019 which claims the benefit of and priority of the prior Chinese patent applications CN 2018104504566 submitted to China National Intellectual Property Administration on May 11 2018 which is entitled Meloxicam composition Aug 25 2019 Meloxicam is an oxicam derivative with the following chemical structure Meloxicam has an empirical formula of C 14 H 13 N 3 O 4 S 2 and a molecular weight of 35141 See The Physicians Desk Reference 56th Ed pp 1054 2002 and The Merck Index 13th Ed pp 10401041 Merck Co 2001 the D09 of the particles of meloxicam is less than 3000 nm the surface weighted mean diameter D32 of the particles of meloxicam is between 100 nm and 800 nm volume weighted mean diameter D43 of the particles of meloxicam is between 400 nm and 1300 nm the dissolution rate of the unit dosage from is such that when tested using USP Apparatus 1 baskets set to rotation speed of US Patent Application for MELOXICAM Justia Patents Search Prior art methods of increasing the bioavailability of meloxicam include increasing its solubility by forming a cyclodextrin complex of the drug see US Pat No 6284269 or by forming a salt of meloxicam with an inorganic or organic base US Patent Publication No 20020035107 A1 Hence the problem of meloxicam liquid formulations having an unpleasant bad taste can be solved by maintaining the pH of such liquid formulations in the range from 2 to 4 Since the solubility of meloxicam is very low in such liquid formulations with a pH value ranging from 2 to 4 meloxicam has to be kekurangan dan kelebihan saat interview formulated as a suspension
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