riuh4d - With the increasing incidence of thoracic harga pintu tumors radiation therapy RT has become an important component of comprehensive treatment RT improves survival in many cancers but it involves some inevitable complications Radiationinduced heart disease RIHD is one of the most serious complications Radiationinduced heart disease a review of classification PubMed Radiation induced heart disease Pathogenesis management and review RadiationInduced Vascular DiseaseA StateoftheArt Review Radiationinduced heart disease A practical guide to diagnosis and In 1995 Early Breast Cancer Trialists Collaborative Group EBCTCG has reported the excess non breast cancer related mortality in irradiated patients after 10 years of follow up 77 versus 57 7Later in a study of 42000 women in 78 randomized trials it was reported that there is an increase in nonbreast cancer mortality rate after 15 years of radiation Radiationinduced heart disease RIHD is a recognized late sequela of chest radiotherapy for conditions such as breast cancer and lymphoma and can involve any cardiac structure Consensus guidelines from the European Association of Cardiovascular Imaging and the American Society of Echocardiography stress the importance of regular screening for the cardiac effects of radiotherapy However a AB Histologic section of the left circumflex coronary artery from a 67yearold patient who received radiation therapy for carcinoma of the lung 7 years prior to sudden death Low power view A demonstrates severe adventitial fibrosis and focally extensive destruction of the media arrowheads with intimal plaque p causing 75 luminal narrowing An overview of radiationinduced heart disease PubMed Radiation therapy RT has dramatically improved cancer survival leading to several inevitable complications Unintentional irradiation of the heart can lead to radiationinduced heart disease RIHD including cardiomyopathy pericarditis coronary artery disease valvular heart disease and condu Younger age at the time not angka cicak cicak di dinding of radiotherapy is associated with an increased risk of RIHD in breast cancer and lymphoma patients A retrospective analysis of 635 patients under age 21 with Hodgkin lymphoma treated with radiotherapy showed a relative risk of fatal myocardial infarction of 415 compared with a general population matched for age sex and race6 RadiationInduced Heart Disease Toward Better and Earlier Detection Cancer patients who receive highdose thoracic radiotherapy may develop radiationinduced heart disease RIHD The clinical presentation of RIHD comprises coronary artery atherosclerosis valvular disease pericarditis cardiomyopathy and conduction defects These complications have significantly RadiationInduced Cardiovascular Toxicities Radiotherapyinduced heart disease a review of the literature Abstract Radiotherapy as one of the four pillars of cancer therapy plays a critical role in the multimodal treatment of thoracic cancers Due to significant improvements in overall cancer survival radiotherapyinduced heart disease RIHD has become an increasingly recognized adverse reaction which contributes to major radiationassociated toxicities including nonmalignant death New Insights into the Understanding of Mechanisms of RadiationInduced Advances in radiationinduced heart disease diagnosis and treatment Apart from RTrelated factors patient conditions also influence the presentation of RIHD A multicenter study involving 2524 patients with Hodgkins lymphoma demonstrated that younger patients were more susceptible to developing RIHD 9 Women with breast cancer and a history of ischemic heart disease and hypertension evidently show a higher risk of major coronary events postRT than those Several seminal papers over the last decade have furthered our recognition of radiationinduced heart disease RIHD as an important potential toxicity following radiation therapy RT to the chest Investigators continue to evaluate the subacute and longterm effects of RT In addition studies are determining whether certain cardiac substructures are more sensitive www.nontongp.lol to radiation working to
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